Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals

ABSTRACT: Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChip™ arrays, one mouse per array.

ORGANISM(S): Mus musculus

SUBMITTER: Yaacov Barak 

PROVIDER: E-GEOD-9130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

A mouse model of conditional lipodystrophy.

Kim Suyeon S   Huang Li-Wen LW   Snow Kathy J KJ   Ablamunits Vitaly V   Hasham Muneer G MG   Young Timothy H TH   Paulk Angelique C AC   Richardson Joel E JE   Affourtit Jason P JP   Shalom-Barak Tali T   Bult Carol J CJ   Barak Yaacov Y  

Proceedings of the National Academy of Sciences of the United States of America 20071005 42

Lipodystrophies are syndromes of adipose tissue degeneration associated with severe defects in lipid and glucose homeostasis. We report here the generation and analysis of Pparg(ldi), a targeted allele that confers conditional dominant lipodystrophy in mice. The Pparg(ldi) allele was generated by insertion of the Tet activator (tTA) and a tTA-regulated Flag-Pparg1 transgene into the Pparg gene. Unexpectedly, tTA elicits mild lipodystrophy, insulin resistance, and dyslipidemia, and the Flag-PPARg  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of mouse adipose tissue from Pparg<ldi/+> animals
2008-06-16 | E-GEOD-9131 | biostudies-arrayexpress
Transcriptomics aP2-nSREBP1c_white_Adipose_Tissue_expression_differentials
2007-09-22 | GSE9130 | GEO
Transcriptomics White adipose tissue from aP2-Pex5 knockout and control mice
2012-03-01 | E-GEOD-31940 | biostudies-arrayexpress
Transcriptomics White adipose tissue from aP2-Pex5 knockout and control mice
2012-03-01 | GSE31940 | GEO
Transcriptomics Transcription profiling of mouse adipocytes and white adipose tissue of mice maintained on normal chow or high fat diet
2009-03-07 | E-GEOD-14363 | biostudies-arrayexpress
Transcriptomics RNA-Sequencing analysis of adipose tissue from obese WT mice and AP2-Cre MCT1 knockout mice
2021-10-01 | GSE184760 | GEO
Transcriptomics Induction of target genes of AP2-Sp in AP2-O::Sp parasites
2010-06-20 | E-GEOD-18910 | biostudies-arrayexpress
Transcriptomics The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (Microarray)
2016-07-20 | E-GEOD-79164 | biostudies-arrayexpress
Transcriptomics adipose tissue Glut4 overexpression or knockout
2012-01-28 | E-GEOD-35378 | biostudies-arrayexpress
Transcriptomics Induction of target genes of AP2-Sp in AP2-O::Sp parasites
2009-11-09 | GSE18910 | GEO