Transcription profiling of mouse parental cell line YAMC, plus bleo/Neo vector control, mp53-expressing, Ras-expressing and mp53/Ras cells reveals a synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

ABSTRACT: Understanding the molecular underpinnings of cancer is of critical importance to developing targeted intervention strategies. Identification of such targets, however, is notoriously difficult and unpredictable. Malignant cell transformation requires the cooperation of a few oncogenic mutations that cause substantial reorganization of many cell features and induce complex changes in gene expression patterns. Genes critical to this multi-faceted cellular phenotype thus only have been identified following signaling pathway analysis or on an ad hoc basis. Our observations that cell transformation by cooperating oncogenic lesions depends on synergistic modulation of downstream signaling circuitry suggest that malignant transformation is a highly cooperative process, involving synergy at multip

ORGANISM(S): Mus musculus

SUBMITTER: Hartmut Land 

PROVIDER: E-GEOD-9199 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress