Transcription profiling of mouse lung after ventilator induced injury reveals genetic and pharmacologic evidence links oxidative stress

ABSTRACT: RATIONALE: Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome. However, the mechanisms by which conventional MV induces lung injury remain unclear. OBJECTIVES: We hypothesized that disruption of the gene encoding Nrf2, a transcription factor which regulates the induction of several antioxidant enzymes, enhances susceptibility to ventilator-induced lung injury (VILI), while antioxidant supplementation attenuates such effect. METHODS: To test our hypothesis and to examine the relevance of oxidative stress in VILI, here we have assessed lung injury and inflammatory responses in Nrf2-deficient (Nrf2(-/-)) mice and wildtype (Nrf2(+/+)) animals following acute (2 h) injurious model of MV with or w

ORGANISM(S): Mus musculus

SUBMITTER: Dmitry Grigoryev 

PROVIDER: E-GEOD-9208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress