Transcription profiling of human bronchial epithelial cells overexpressing the lung developmental transcription factors TTF1, NKX2-8 and PAX9

ABSTRACT: We investigated the clinical implications of lung developmental transcription factors (TTF-1, NKX2-8, and PAX9) which we recently discovered as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer. Using stable transfectants of human bronchial epithelial cells, RNA expression profiles (signatures) representing activation of the biological pathways defined by each of the three genes were determined and used to risk stratify a non-small cell lung cancer (NSCLC) clinical dataset consisting of ninety-one early stage tumors. Co-activation of the TTF-1 and NKX2-8 pathways identified a cluster of patients with poor survival, representing approximately 20% of patients with early stage NSCLC, whereas activation of individual pathways did not reveal signifi

ORGANISM(S): Homo sapiens

SUBMITTER: Chaitanya Ramanuj Acharya 

PROVIDER: E-GEOD-9212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress