Genome-wide localization of Ino80 and Arp5 on chromosome in Saccharomyces cerevisiae

ABSTRACT: Background: Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires actin-related proteins, Arp4, Arp5 and Arp8, as well as two RuvB-like DNA helicase subunits. Budding yeast mutants deficient for Ino80 function are not only hypersensitive to reagents that induce DNA double strand breaks, but also to those that impair replication fork progression. Results: To understand why ino80 mutants are sensitive to agents that perturb DNA replication, we used chromatin immunoprecipitation to map the binding sites of the Ino80 chromatin remodeling complex on four budding yeas

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Yukako Oma 

PROVIDER: E-GEOD-9233 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress