Systems biology of gene expression of bladder papilloma cells modulated by a malignant-derived extracellular matrix

ABSTRACT: This study was undertaken to identify how gene expression of the RT4 bladder papilloma cells respond to extracellular matrics (ECM) Matrigel. Gene expression profile of RT4 cells grown on Plastic was compared with expression profiles of RT4 cells grown on Matriges over 12 hours-9 days timecourse. Total 5881 hypervariable (HV) genes were found to vary significantly over the time points, indicating a response to matrix change. Correlational clustering showed these HV genes fell into distinct families, predominantly genes which became highly expressed on ECM. Another cluster show genes expressed at 12 hours after grown on Matrigel and third cluster show genes whose expression decreased below noise level on Matrigel. This indicate that processes responsible for cell adaptation to ECM happen wi

ORGANISM(S): Homo sapiens

SUBMITTER: Igor Dozmorov 

PROVIDER: E-GEOD-9291 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress