Transcription profiling of rat ovary during primordial follicle assembly and development.

ABSTRACT: The assembly of the developmentally arrested primordial follicle and subsequent transition to the primary follicle are poorly understood processes critical to ovarian biology. Abnormal primordial follicle development can lead to pathologies such as premature ovarian failure. The current study used a genome-wide expression profile to investigate primordial follicle assembly and development. Rat ovaries with predominantly unassembled, primordial, or primary follicles were obtained. RNA from these ovaries was hybridized to rat microarray gene chips, and the gene expression (i.e., ovarian transcriptome) was compared between the developmental stages. Analysis of the ovarian transcriptome demonstrated 148 genes up-regulated and 50 genes down-regulated between the unassembled and primordial folli

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Skinner 

PROVIDER: E-GEOD-9300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress