Transcription profiling of mouse lung with recombinant human soluble PBEFtreatment and ventilator-induced lung injury

ABSTRACT: We have previously demonstrated that pre-B-cell colony enhancing factor (PBEF) ais a biomarker in sepsis and sepsis-induced acute lung injury (ALI) with genetic variants conferring ALI susceptibility118. In the current study, we explored the mechanistic participation of PBEF in ALI and ventilator-induced associated lung injury (VIALI). Initial in vitro studies and demonstrated rhPBEF aas a direct rat neutrophil chemotactic factor in vitro producing marked in vivo increases in BAL leukocytes (PMNs) in vivo following (intratracheal injection (,IT) in C57B6 mice. These latter changes were accompanied by increased BAL levels of the PMN chemoattractants (, KC and MIP2), and modest changes in lung vascular and but were not associated with significant increasesin alveolar permeability. We next ex

ORGANISM(S): Mus musculus

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-9314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress