Transcription profiling of mouse subspecies and their F1 hybrids for 3 tissues (brain, liver, testis)

ABSTRACT: We have studied different subspecies of the house mouse (M. m. musculus, M. m. domesticus and M. m. castaneus) and their reciprocal F1 hybrids to estimate the within-locus mode of inheritance for subspecies differences in gene expression in three tissues (brain, liver, testis) of male mice. This study investigates mode of inheritance in crosses at a larger taxonomic distance than have been previously systematically investigated. We found the vast majority of transcripts to be additively expressed with only a few transcripts showing dominance or overdominance in expression, except for one direction of one cross, which showed large mis-expression in the testis. Experiment Overall Design: Wild-derived inbred lines of M. m. musculus, M. m. domesticus and M. m. castaneus were used to generate r

ORGANISM(S): Mus musculus musculus x Mus musculus castaneus

SUBMITTER: Ruth Rottscheidt 

PROVIDER: E-GEOD-9338 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress