Transcription profiling of mouse mammary tumours developed in Wap-Cre;Etv6-NTRK3 mice

ABSTRACT: We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre leads to fully penetrant, multifocal malignant breast cancer with short latency. We provide genetic evidence that committed bipotent or CD61+ luminal alveolar progenitors, are targets of tumorigenesis. Furthermore, EN transforms these otherwise transient progenitors through activation of the AP1 complex. Given increasing relevance of chromosomal translocations in epithelial cancers, such mice serve as a paradigm for the study of their genetic pathogenesis and cellular origins, and generation of nove

ORGANISM(S): Mus musculus

SUBMITTER: Zhe Li 

PROVIDER: E-GEOD-9355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress