Transcriptomic and proteomic profiling reveal insights of mesangial cell function in patients with IgA Nephropathy

ABSTRACT: IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The disease is characterized by galactose deficient IgA (gd-IgA) in the circulation forming immune complexes. The complexes are deposited in the glomerular mesangium leading to inflammation and loss of renal function, but the pathophysiology of the disease is still not fully understood. Using an integrated global transcriptomic and proteomic profiling approach we investigated the role of the mesangium in the onset and progression of IgAN. Global gene expression was investigated by microarray analysis of the glomerular compartment of renal biopsies from patients with IgAN. The influence of galactose deficient IgA (gd-IgA) on mesangial cells was investigated by proteomic profiling. By utilizing the previous published

ORGANISM(S): Homo sapiens

SUBMITTER: Celine Berthier 

PROVIDER: E-GEOD-93798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress