Effects of nitric oxide on Salmonella adapted at pH 4.4

ABSTRACT: Reactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrates (NO3-) foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antibiotic activity in the gastric lumen are, however, poorly understood. To identify targets of RNS, the genetically tractable acid tolerance response (ATR) that enables enteropathogens to survive the harsh acidity of the stomach was screened for signaling pathways responsive to RNS. The nitric oxide (NO) donor spermine NONOate derepressed the Fur regulon that controls secondary lines of resistance against organic acids. Despite inducing a Fur-mediated adaptive response, acidified RNS largely boosted gastric host defenses as demonstrated by the fact that Salmonella bacteri

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium

SUBMITTER: Rui Zhao 

PROVIDER: E-GEOD-9398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress