Transcription profiling of human skin biopsies in cutaneous T-cell lymphoma

ABSTRACT: Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disease and its management. Based on 63 skin samples, we performed consensus clustering, revealing three patient clusters. Two clusters tended to differentiate limited CTCL (stages IA and IB) from more extensive CTCL (stages IB and III). Stage IB subjects appeared in both clusters, but those in the limited CTCL cluster were more responsive to treatment than those in the more extensive CTCL cluster. The third cluster was enriched in lymphocyte activation genes and was associated with a high proportion

ORGANISM(S): Homo sapiens

SUBMITTER: Jessica Shin 

PROVIDER: E-GEOD-9479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress