Transcription profiling of mouse C57BL/6 Mouse Embryo Culture Model treated with ethanol

ABSTRACT: Mouse model for Fetal Alcohol Syndrome. Embryos exposed to alcohol in controlled environment to assess teratogenic effects. Fetal Alcohol Syndrome (FAS) is a leading developmental disorder. To date, a holistic view of molecular gene changes is largely unexplored. Using microarray analysis of whole embryo mouse culture with strict-control over alcohol-level, we found, directly related alcohol-metabolism, a reduction of retinol binding protein 1(Rbp1), and a, de novo expression of aldehyde dehydrogenase 1B1 (ALDH1B1). Remarkably, four key hemopoiesis genes (glycophorin A, adducin 2, beta-2 microglobulin, and ceruloplasmin) became absent, and many histone variants genes were reduced. Hypothesis-driven informatics analysis and intersection analysis of two independent experiments indicated t

ORGANISM(S): Mus musculus

SUBMITTER: Feng Zhou 

PROVIDER: E-GEOD-9545 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress