Transcription profiling of mouse whole skin from pRB deficient animals reveals that p107 acts as a tumor suppressor

ABSTRACT: The specific deletion of Rb gene in epidermis leads to altered proliferation and differentiation, but not to the development of spontaneous tumors. Our previous data have demonstrated the existence of a functional compensation of Rb loss by Rbl1 (p107) in as the phenotypic differences with respect to controls are intensified. However, the possible evolution of this aggravated phenotype, in particular in relationship with tumorigenesis, has not been evaluated due to the premature death of the double deficient mice. We have now investigated whether p107 can also act as a tumor suppressor in pRb-deficient epidermis using different experimental approaches. We found spontaneous tumor development in doubly-deficient skin grafts. Moreover, Rb-deficient keratinocytes are susceptible to Ha-ras-indu

ORGANISM(S): Mus musculus

SUBMITTER: Ramón García-Escudero 

PROVIDER: E-GEOD-9567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress