Transcription profiling of rat embryonic kidney timepoints and a budded WD-MM recombination tissue

ABSTRACT: Here we compared the expression of an engineered kidney tissue, created by recombining an in vitro budded Wolffian duct with fresh E13 metanephric mesenchyme, with that of three in vivo rat embryonic kidney timepoints (E13, E18, and week 4) Experiment Overall Design: The global gene expression of recombined tissue (non-branched in vitro-formed UBs and MM) was analyzed and compared to the gene expression of early, late, and post developmental kidneys in order to determine whether normal developmental pathways were being followed. Genes with at least a 3-fold difference in expression between any of the 4 conditions (E13, E18, Wk4, recombined tissue) were analyzed and grouped into one of ten expression patterns. The expression of each group of genes was analyzed in the recombined tissue to co

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sanjay Nigam 

PROVIDER: E-GEOD-9570 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress