Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human pancreatic cancer samples: coordinated over-expression of genes in the EGFR pathway predicts sensitivity to EGFR inhibition

ABSTRACT: Tumors from pancreatic cancer specimens obtained at surgery were used for efficacy testing and biologic analysis Experiment Overall Design: Eighteen tumor samples were profiled in duplicates. Ten samples were used in the training set and eight samples were used as the validation set.

ORGANISM(S): Homo sapiens

SUBMITTER: Aik Choon Tan 

PROVIDER: E-GEOD-9599 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.

Jimeno Antonio A   Tan Aik Choon AC   Coffa Jordy J   Rajeshkumar N V NV   Kulesza Peter P   Rubio-Viqueira Belen B   Wheelhouse Jenna J   Diosdado Begoña B   Messersmith Wells A WA   Iacobuzio-Donahue Christine C   Maitra Anirban A   Varella-Garcia Marileila M   Hirsch Fred R FR   Meijer Gerrit A GA   Hidalgo Manuel M  

Cancer research 20080401 8

The epidermal growth factor receptor (EGFR) inhibitor erlotinib is approved for treatment of pancreatic cancer but the overall activity is minimal, and known predictive factors for EGFR inhibitor efficacy are infrequent in this disease. We tested the hypothesis that global activation of the EGFR pathway is predictive of EGFR inhibitor efficacy. Pancreatic cancer tumors directly xenografted at surgery were treated with the EGFR inhibitors erlotinib and cetuximab and analyzed for biological featur  ...[more]

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