Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma

ABSTRACT: Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; cetuximab, a monoclonal antibody (mAb) against Epidermal Growth Factor Receptor (EGFR), and AMG 479, a mAb against Insulin-like Growth Factor-1 Receptor (IGF-1R). In tumor tissue of this patient we observed gene expression modulation by cetuximab and AMG 479 suggesting crosstalk between the EGFR and IGF-1R pathways that may have sensitized the tumor to MTX. This represents a promising novel approach to development of targeted agents in refractory cancer. Keywords: tumor response 10 samples from different time points during course of treatment in a single individual.

ORGANISM(S): Homo sapiens

SUBMITTER: Christine Chung 

PROVIDER: E-GEOD-9600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma.

Chung Christine H CH   Pohlmann Paula R PR   Rothenberg Mace L ML   Burkey Brian B BB   Parker Joel J   Palka Kevin K   Aulino Joseph J   Puzanov Igor I   Murphy Barbara B  

Head & neck 20100722 12

<h4>Background</h4>Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]).<h4>Methods</h4>The clinical information was collected by a retrospective medical record review under an Institutional Review Board-approved protocol. Fr  ...[more]

Similar Datasets

Transcriptomics Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma
2010-08-03 | GSE9600 | GEO
Transcriptomics Gene expression associated with panitumumab efficacy in squamous cell carcinoma of head and neck
2019-01-23 | GSE102995 | GEO
Other Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines
2020-01-29 | GSE132788 | GEO
Transcriptomics An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases
2016-03-22 | E-GEOD-67500 | biostudies-arrayexpress
Genomics An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases
2016-03-22 | GSE67500 | GEO
Transcriptomics The expression profile of Cetuximab resistance in head-and-neck squamous cell carcinoma cells.
2017-03-02 | GSE63916 | GEO
Transcriptomics Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
2012-05-22 | E-GEOD-32975 | biostudies-arrayexpress
Transcriptomics Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
2012-05-23 | GSE32975 | GEO
Transcriptomics Knockdown IGF-1R triggers viral RNA sensors MDA5- and RIG-1-mediated the mitochondrial apoptosis in colonic cancer cells
2019-11-30 | GSE122534 | GEO
Genomics Integrated single cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC sensitive cell lines
2020-05-04 | GSE135604 | GEO