MacroH2A1 ChIP-chip
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: William Kraus
PROVIDER: E-GEOD-9607 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing.
Gamble Matthew J MJ Frizzell Kristine M KM Yang Christine C Krishnakumar Raga R Kraus W Lee WL
Genes & development 20091215 1
MacroH2A1 is a histone variant that is enriched on the inactive X chromosome (Xi) in mammals and is postulated to play an important, but unknown, role in the repression of gene expression. Here we show that, although macroH2A1 marks repressed autosomal chromatin, it positively regulates transcription when located in the transcribed regions of a subset of its target genes. We used chromatin immunoprecipitation (ChIP) coupled with tiling microarrays (ChIP-chip) to determine the genomic localizatio ...[more]
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