Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray

ABSTRACT: Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Phox2b. Phox2b in particular plays a key role in the specification of branchiomotor neurons. In its absence, generic neuronal differentiation is defective in the progenitor domain, and no branchiomotor neurons are produced. Conversely, ectopic expression of Phox2b in spinal regions of the neural tube promotes cell cycle exit and neuronal differentiation and at the same time induces genes and an axonal phenotype characteristic for branchiomotor neurons. How Phox2b exerts its pleiotropic functions,

ORGANISM(S): Mus musculus

SUBMITTER: Stephane Le Crom 

PROVIDER: E-GEOD-9619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress