Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lee Denson
PROVIDER: E-GEOD-9686 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Inflammatory bowel diseases 20080401 4
<h4>Background</h4>While activation of the IL-6-dependent transcription factor signal transducer and activator of transcription 3 (STAT3) has been implicated in the pathogenesis of inflammatory bowel disease (IBD), a direct effect on mucosal gene expression and inflammation has not been shown. We hypothesized that a proinflammatory IL-6:STAT3-dependent biological network would be up regulated in pediatric-onset IBD patients, and would be associated with the severity of mucosal inflammation.<h4>M ...[more]