Transcription profiling of rat Wistar Kyoto and spontaneously hypertensive strains to diesel exhaust particle exposure.

ABSTRACT: DEP exposure is linked to increases in cardiovascular effects. This effect is enhanced in individuals with pre-existing disease. Animal models of cardiovascular disease are used to study this susceptibility. The heart is rich in mitochondria, which produce high levels of free radicals, leading to inactivation of tricarboxylic acid cycle enzymes. We hypothesized that a 4-wk DEP inhalation would result in strain-related structural impairment of cardiac mitochondria and changes in these enzyme activities in WKY and SHR. Male rats (12-14 wks age) were exposed whole body to air or 0.5 or 2.0 mg/m3 DEP for 6h/d, 5 d/wk for 4 wks. Neutrophilic influx was noted in the bronchoalveolar lavage fluid in both strains. A slightly lower level of baseline cardiac mitochondrial aconitase activity was seen

ORGANISM(S): Rattus norvegicus

SUBMITTER: Urmila Kodavanti 

PROVIDER: E-GEOD-9694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress