Identification of Common Genetic Variants that Account for Transcript Isoform Variation between Human Populations

ABSTRACT: In addition to the differences between populations in transcriptional and translational regulation of genes, alternative pre-mRNA splicing (AS) is also likely to play an important role in regulating gene expression and generating variation in mRNA and protein isoforms. Recently, the genetic contribution to transcript isoform variation has been reported in individuals of recent European descent. We report here results of an investigation of the differences in AS patterns between human populations. AS patterns in 176 HapMap lymphoblastoid cell lines derived from individuals of European and African ancestry were evaluated using the Affymetrix GeneChip Human Exon 1.0 ST Array. A variety of biological processes such as immune response and mRNA metabolic process were found to be enriched among t

ORGANISM(S): Homo sapiens

SUBMITTER: Wei Zhang 

PROVIDER: E-GEOD-9703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress