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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human radioresistant and radiosensitive tumors and cell lines

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE9712: Detection of genes differentially expressed in radioresistant tumors; GSE9713: Detection of genes differentially expressed in radioresistant and radiosensitive tumors before and after irradiation; GSE9714: Interferon response of radioresistant and radiosensitive human head&neck tumor cell lines Experiment Overall Design: Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Nikolai Khodarev

PROVIDER: E-GEOD-9716 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.

Khodarev Nikolai N NN Beckett Michael M Labay Edwardine E Darga Thomas T Roizman Bernard B Weichselbaum Ralph R RR

Proceedings of the National Academy of Sciences of the United States of America 20040130 6

Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Replicate DNA array experiments identified 52 genes differentially expressed in nu61 tumors compared with SCC-61 tumors. Of these, 19 genes were in the IFN-signaling pathway and moreover, 25 of the 52 genes were inducible by IFN in the nu61 cell line. Among the genes involved in IFN signaling, STAT1alpha and ST ...[more]

PMID: 14755057

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Transcription profiling of human radioresistant tumor xenografts from athymic nude mice to detect genes differentially expressed in radioresistant tumors

Project description:Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors were profiled using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway Experiment Overall Design: Obtained tumors were established as xenografts in nude mice. RNA were purified from each xenograft, normalized by concentration and three samples of RNA from each group were pooled for hybridization with each array. Three arrays were used for each group.

2008-06-16 | E-GEOD-9712 | biostudies-arrayexpress

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Comparative analysis of gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

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DNA copy number alteration analysis of radioresistant and radiosensitive prostate cancer cell lines

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Detection of genes differentially expressed in radioresistant and radiosensitive tumors before and after irradiation

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Mevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer

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Copy number variation comparison between control and CC214-2 resistant GBM39 xenografts

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