Transcription profiling of mouse neurite outgrowth and regeneration

ABSTRACT: We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and regenerative responses to axotomy, which occurs as the result of tissue dissection. Comparison across both models revealed many genes with similar gene expression patterns during neurite outgrowth. These patterns were minimally affected by exposure to the potent inhibitory cue Semaphorin3A, indicating that this extrinsic cue does not exert major effects at the level of nuclear transcription. We also compared our data to several published studies of DRG and SCG gene expression in animal models

ORGANISM(S): Mus musculus

SUBMITTER: Moriah Szpara 

PROVIDER: E-GEOD-9738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress