Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic analysis for Pch/ Ler regulon in enterohaemorrhagic Escherichia coli O157:H7

ABSTRACT: Enterohaemorrhagic Escherichia coli (EHEC) is an emerging pathogen that causes diarrhea and heamolytic uremic syndrome. Much of the genomic information that affects virulence is acquired via horizontal transfer. Genes necessary for attaching and effacing lesions are located in the LEE pathogenicity island. LEE gene transcription is positively regulated by Ler, which is also encoded by the LEE, and by Pch regulators, which are encoded at other loci. We identified genes whose transcription profiles were similar to those of the LEE genes, by comparing the effects of altering ler and pch transcript levels. We assigned these genes into two classes, according to their transcription profiles. 13 sets of comparison between transcription profiles in strains with different pch or ler genotypes. Labelling of cDNA and hybridization were performed twice with independently prepared RNAs.

ORGANISM(S): Escherichia coli O157:H7 str. Sakai

SUBMITTER: Hiroyuki Abe 

PROVIDER: E-GEOD-9752 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global regulation by horizontally transferred regulators establishes the pathogenicity of Escherichia coli.

Abe Hiroyuki H   Miyahara Akira A   Oshima Taku T   Tashiro Kosuke K   Ogura Yoshitoshi Y   Kuhara Satoru S   Ogasawara Naotake N   Hayashi Tetsuya T   Tobe Toru T  

DNA research : an international journal for rapid publication of reports on genes and genomes 20080125 1

Enterohemorrhagic Escherichia coli is an emerging pathogen that causes diarrhea and hemolytic uremic syndrome. Much of the genomic information that affects virulence is acquired by horizontal transfer. Genes necessary for attaching and effacing lesions are located in the locus for enterocyte effacement (LEE) pathogenicity island. LEE gene transcription is positively regulated by Ler, which is also encoded by the LEE, and by Pch regulators, which are encoded at other loci. Here we identified gene  ...[more]

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