Transcription profiling of mouse striatum from 12 weeks-old R6/2 mice and control mice (set 1)

ABSTRACT: To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic models expressing short N-terminal fragments of mutant huntingtin (R6/1 and R6/2 mice) exhibited the most rapid effects on gene expression, consistent with previous studies. Although changes in the brains of knock-in and full-length transgenic models of HD took longer to appear, 15- and 22-month CHL2(Q150/Q150), 18-month Hdh(Q92/Q92) and 2-year-old YAC128 animals also exhibited significant HD-like mRNA signatures. Whereas it was expected that the expression of full-length huntingtin transprotein

ORGANISM(S): Mus musculus

SUBMITTER: Alexandre Kuhn 

PROVIDER: E-GEOD-9803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress