Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Derek Chiang
PROVIDER: E-GEOD-9829 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.
Chiang Derek Y DY Villanueva Augusto A Hoshida Yujin Y Peix Judit J Newell Philippa P Minguez Beatriz B LeBlanc Amanda C AC Donovan Diana J DJ Thung Swan N SN Solé Manel M Tovar Victoria V Alsinet Clara C Ramos Alex H AH Barretina Jordi J Roayaie Sasan S Schwartz Myron M Waxman Samuel S Bruix Jordi J Mazzaferro Vincenzo V Ligon Azra H AH Najfeld Vesna V Friedman Scott L SL Sellers William R WR Meyerson Matthew M Llovet Josep M JM
Cancer research 20080801 16
Hepatocellular carcinomas represent the third leading cause of cancer-related deaths worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B virus or hepatitis C virus infection. To identify genetic mechanisms of hepatocarcinogenesis, we characterized copy number alterations and gene expression profiles from the same set of tumors associated with hepatitis C virus. Most tumors harbored 1q gain, 8q gain, or 8p loss, with occasional alterations in 13 a ...[more]
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