Transcription profiling of S. cerevisiae strains containing the essential histone acetyltransferase, ESA1 or a bypass suppressor of ESA1

ABSTRACT: ESA1 (essential SAS-family acetyltransferase) is the only known yeast histone acetyltransferase (HAT) required for cell viability. It is a member of the MYST (MOZ, YBF2/SAS3, SAS2, Tip60) family of HAT proteins and contains a conserved acetyltransferase domain in addition to a chromodomain. While ESA1’s HAT activity is important in processes such as deoxyribonucleic acid (DNA) repair, acetylation is likely not its essential function. Our lab has shown that mutants with a single point mutation in the active site cysteine are still viable even though their acetyltransferase abilities are abolished. Furthermore, chromatin immunoprecipitation assays have shown ESA1 distributed evenly along the length of chromatin, not localized to specific promoters as would be expected from a HAT protein in

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Courtney Sill 

PROVIDER: E-GEOD-9840 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress