Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4

ABSTRACT: Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to diverse immune diseases, such as B-cell lymphoma or autoimmunity, that often affect humans. Identification of genes that restrain uncontrolled proliferation of B cells is therefore an important goal towards understanding the origin of such diseases. Here we identify Ptger4 as a negative feedback regulator of B-cell proliferation in response to BCR triggering, and show that its encoded EP4 receptor is a principal molecule conveying the growth-suppressive effect of prostaglandin E2 (PGE2). In contr

ORGANISM(S): Mus musculus

SUBMITTER: Olivier ALIBERT 

PROVIDER: E-GEOD-9847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress