Gene expression changes associated with the anti-angiogenic effect of KLK3 (PSA) on HUVECs

ABSTRACT: Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific antigen, PSA) is a chymotrypsin-like kallikrein that has been shown to have anti-angiogenic properties. KLK3 expression in prostate cancer is associated with low microvessel density. We have previously shown in a human umbilical vein endothelial cell (HUVEC) model that the anti-angiogenic effect of KLK3 is related to its enzymatic activity. However, the mechanism of this effect remains to be clarified. To this end we have used a DNA microarray to study the KLK3-induced changes in gene expression associated with reduction of HUVEC tube formation. Among the 41000 genes studied, 311 were differentially expressed in control and KLK3-treated cells. These changes were enriched in several pathways, including the pathways associ

ORGANISM(S): Homo sapiens

SUBMITTER: Hannu Koistinen 

PROVIDER: E-GEOD-9869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress