Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse livers from growth hormone receptor (GHR) deficient mice and mice expressing different forms of truncated GHR to study the GHR signaling domains and their associated transcripts.

ABSTRACT: Total RNA was extracted from mouse liver samples using an Ambion RNaqueous RNA extraction kit. Targets were produced using modified Affymetrix procedure from 5ug of total RNA. 3 biological replicates were analysed per each group of animals.

ORGANISM(S): Mus musculus

SUBMITTER: Agnieszka Maria Lichanska 

PROVIDER: E-GEOD-988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In vivo analysis of growth hormone receptor signaling domains and their associated transcripts.

Rowland Jennifer E JE   Lichanska Agnieszka M AM   Kerr Linda M LM   White Mary M   d'Aniello Elisabetta M EM   Maher Sheryl L SL   Brown Richard R   Teasdale Rohan D RD   Noakes Peter G PG   Waters Michael J MJ  

Molecular and cellular biology 20050101 1

The growth hormone receptor (GHR) is a critical regulator of postnatal growth and metabolism. However, the GHR signaling domains and pathways that regulate these processes in vivo are not defined. We report the first knock-in mouse models with deletions of specific domains of the receptor that are required for its in vivo actions. Mice expressing truncations at residue m569 (plus Y539/545-F) and at residue m391 displayed a progressive impairment of postnatal growth with receptor truncation. More  ...[more]

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