Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of C2C12 myoblasts induced to differentiate in vitro over a 12 day time series to identify novel genes involved in myogenic differentiation.

ABSTRACT: In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during myogenic fusion and maturation of multinucleated myotubes (days 2, 4, 6, 8, 10). The manuscript associated to this work is Tomczak et al., FASEB J., 2003 Dec 19. Additionally, the supplementary data can be found on our homepage at http://www.chb-genomics.org/beggslab/

ORGANISM(S): Mus musculus

SUBMITTER: Kinga Katarzyna Tomczak 

PROVIDER: E-GEOD-989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression profiling and identification of novel genes involved in myogenic differentiation.

Tomczak Kinga K KK   Marinescu Voichita D VD   Ramoni Marco F MF   Sanoudou Despina D   Montanaro Federica F   Han Mei M   Kunkel Louis M LM   Kohane Isaac S IS   Beggs Alan H AH  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031219 2

Skeletal muscle differentiation is a complex, highly coordinated process that relies on precise temporal gene expression patterns. To better understand this cascade of transcriptional events, we used expression profiling to analyze gene expression in a 12-day time course of differentiating C2C12 myoblasts. Cluster analysis specific for time-ordered microarray experiments classified 2895 genes and ESTs with variable expression levels between proliferating and differentiating cells into 22 cluster  ...[more]

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