Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human acute myeloid leukemia cells to identify compounds inducing the differentiation of acute myeloid leukemia cells

ABSTRACT: We developed a general approach to small molecule library screening called GE-HTS (Gene Expression-Based High Throughput Screening) in which a gene expression signature is used as a surrogate for cellular states and applied it to the identification of compounds inducing the differentiation of acute myeloid leukemia cells. In screening 1,739 compounds, we identified 8 that reliably induced the differentiation signature, and furthermore yielded functional evidence of bona fide differentiation. This SuperSeries is composed of the following subset Series:; GSE976: Gene Expression-Based High Throughput Screening: APL Treatment with Candidate Compounds; GSE982: Gene Expression-Based High Throughput Screening: HL-60 Cell Treatment with Candidate Compounds; GSE983: Gene Expression-Based High Throughput Screening: Primary Patient AML Blasts, Normal Neutrophils, and Normal Monocytes; GSE985: Gene Expression-Based High Throughput Screening: HL-60 Cells Treated with ATRA and PMA Experiment Overall Design: Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Ken Ross 

PROVIDER: E-GEOD-995 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation.

Stegmaier Kimberly K   Ross Kenneth N KN   Colavito Sierra A SA   O'Malley Shawn S   Stockwell Brent R BR   Golub Todd R TR  

Nature genetics 20040208 3

Chemical genomics involves generating large collections of small molecules and using them to modulate cellular states. Despite recent progress in the systematic synthesis of structurally diverse compounds, their use in screens of cellular circuitry is still an ad hoc process. Here, we outline a general, efficient approach called gene expression-based high-throughput screening (GE-HTS) in which a gene expression signature is used as a surrogate for cellular states, and we describe its application  ...[more]

Similar Datasets

Genomics Homo sapiens
| PRJNA89873 | ENA
Unknown Gene Expression-Based High Throughput Screening: HL-60 Cell Treatment with Candidate Compounds
2004-01-30 | GSE982 | GEO
Unknown Gene Expression-Based High Throughput Screening: HL-60 Cells Treated with ATRA and PMA
2004-01-30 | GSE985 | GEO
Unknown Differentiation of acute myeloid leukemia cells
2004-01-30 | GSE995 | GEO
Genomics Homo sapiens
| PRJNA89871 | ENA
Genomics Homo sapiens
| PRJNA89877 | ENA
Genomics Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds
| PRJNA671726 | ENA
Unknown High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets
2023-01-28 | GSE223599 | GEO
Unknown Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds
2020-12-31 | GSE160071 | GEO
Unknown Gene Expression-Based High Throughput Screening: APL Treatment with Candidate Compounds
2004-01-30 | GSE976 | GEO