Transcription profiling of human placentae of different gestational ages: an opru network and uw scor study

ABSTRACT: We used a whole genome approach to identify major functional gene categories (including xenobiotic transporters and metabolizing enzymes) whose expression depends on gestational age. STUDY DESIGN: We compared gene expression profiles of 1st (45-59 days) and 2nd trimester (109-115 days), and C-section term placentae. RESULTS: In 1st trimester placentae, genes related to cell cycle, DNA, aminoacids and carbohydrate metabolism were significantly overrepresented, while genes related to signal transduction were downregulated. In the organism defense category, we identified genes involved in chemical response, metabolism, and transport. Analysis of signal transduction pathways suggested, and subsequently confirmed independently, that the Wnt pathway was regulated by gestational age. CONCLUSION

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-9984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress