Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

ABSTRACT: Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (also known as NKX2-1), previously linked to normal lung development and function. When amplified, TITF1 exhibited increased expression at both the RNA and protein level. siRNA-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis. Our findings indicate that TITF1 amplification and overexpression contribute to lung cancer cell proliferation rates and survival, and implicate TITF1 as a lineage-specific oncogene in lung cancer. This SuperSeries is composed of the following subset Series: GSE9994: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: Expression Arrays GSE10025: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: aCGH Arrays Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jonathan Pollack

PROVIDER: E-GEOD-9995 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

Kwei K A KA Kim Y H YH Girard L L Kao J J Pacyna-Gengelbach M M Salari K K Lee J J Choi Y-L YL Sato M M Wang P P Hernandez-Boussard T T Gazdar A F AF Petersen I I Minna J D JD Pollack J R JR

Oncogene 20080121 25

Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (thyroid transcription factor 1; also called NKX2-1), previously linked to normal lung development and function. When amplif ...[more]

PMID: 18212743

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

Publications

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

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