Single cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity

ABSTRACT: This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Overall design: Using droplet RNA sequencing, transcriptomes of single cells from P7 and P30 murine aortic and mitral heart valves were analyzed.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Alexia Hulin 

PROVIDER: E-HCAD-18 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress