Transcription profiling of brain tissue from wild type and casp1 knock-out mice treated with lipopolysaccharide or sodium chloride

ABSTRACT: The systemic inflammatory response syndrome (SIRS) is a life-threatening medical condition characterized by a severe and generalized inflammatory state that can lead to multiple organ failure and shock. The central nervous system (CNS) regulates many features of SIRS, such as fever, cardiovascular and neuroendocrine responses.

Central and systemic manifestations of SIRS can be induced by LPS or interleukin-1ß (IL-1ß) administration. The crucial role of IL-1ß in inflammation has been further highlighted by studies of mice lacking caspase 1 (casp1, also known as IL-1ß convertase), a protease that cleaves pro-IL-1ß into mature IL-1ß. Indeed, casp1 knockout (casp1-/-) mice survive lethal doses of LPS. The key role of IL-1ß in sickness behavior and its de-novo expression in the CNS du

ORGANISM(S): Mus musculus

SUBMITTER: Claudio Mastronardi 

PROVIDER: E-MEXP-1017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress