Transcription profiling of brain tissue from cerebral malaria-resistant and susceptible strains of mice in a time series following infection with Plasmodium berghei

ABSTRACT: Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (CM-R) and CM-susceptible (CM-S) mice, upon infection by Plasmodium berghei ANKA. We investigated mouse transcriptional responses prior to infection, and at early and late stages of infection by use of cDNA microarrays. Through a rigorous statistical approach with multiple testing corrections, we showed that P. berghei ANKA significantly altered brain gene expression in CM-R (BALB/c), and in CM-S (CBA/J and C57BL/6) mice, and that 327 genes discriminated between early and late infection stages, b

INSTRUMENT(S): FUJIFILM BAS-5000 scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Denis Puthier 

PROVIDER: E-MEXP-1018 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress