Transcription profiling of Ts65Dn vs control mice in nine different mouse tissues

ABSTRACT: To understand the molecular basis of Down syndrome pathogenesis, we performed a transcriptome analysis of nine different tissues in Ts65Dn, an established mouse model of human trisomy 21. Ts65Dn mice have segmental trisomy of mouse chromosome 16 with ca. 128 genes at dosage imbalance (Reeves et al. 1995). The Ts65Dn mouse is widely used as a model for studies of DS because it is at dosage imbalance for the orthologs of about half the 284 Chr21 genes. Ts65Dn mice have several features that directly parallel developmental anomalies of DS. We compare here the expression of 136 mouse orthologs of Chr21 genes, 77 of which are triplicated in Ts65Dn, in trisomic and euploid mice.

We designed a mouse cDNA expression array interrogating 136 mmu21 genes. RNA pools from four adult male Ts6

ORGANISM(S): Mus musculus

SUBMITTER: Marie-Laure Yaspo 

PROVIDER: E-MEXP-102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress