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Transcription profiling of mouse pressure overload induced cardiomyopathy in gp130 knock-out mice

ABSTRACT: Comparison between wild-type and cardiomyocyte-restricted knock-out of IL6 cytokines receptor component gp130 after surgical intervention for pressure-overload induced cardiomyopathy.

ORGANISM(S): Mus musculus

SUBMITTER: Sylvain Pradervand

PROVIDER: E-MEXP-104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

Pashmforoush Mohammad M Lu Jonathan T JT Chen Hanying H Amand Tara St TS Kondo Richard R Pradervand Sylvain S Evans Sylvia M SM Clark Bob B Feramisco James R JR Giles Wayne W Ho Siew Yen SY Benson D Woodrow DW Silberbach Michael M Shou Weinian W Chien Kenneth R KR

Cell 20040401 3

Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unknown mechanisms. To define these pathways, we generated mice with a ventricular-restricted knockout of Nkx2-5, which display no structural defects but have progressive complete heart block, and massive trabecular muscle overgrowth found in some patients with Nkx2-5 mutations. At birth, mutant mice display a hypoplastic atrioventricular (AV) node and then develop selective dropout of these conduction cells. ...[more]

PMID: 15109497

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