Transcription profiling of human lymphocytes from healthy individuals given selenium supplements
Ontology highlight
ABSTRACT:
INSTRUMENT(S): ScanArray Express HT [PerkinElmer]
ORGANISM(S): Homo sapiens
SUBMITTER: Vasileios Pagmantidis
PROVIDER: E-MEXP-1046 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes.
Pagmantidis Vasileios V Méplan Catherine C van Schothorst Evert M EM Keijer Jaap J Hesketh John E JE
The American journal of clinical nutrition 20080101 1
<h4>Background</h4>Selenium is incorporated into 25 selenoproteins in humans. Low dietary selenium has deleterious effects on health and may result in cancer, cardiovascular disease, and immune dysfunction. The underlying mechanisms are not fully understood. Lymphocytes are a target tissue; they can be assessed in healthy persons, and their response has not been explored by using global gene expression profiling techniques.<h4>Objectives</h4>The objectives of the study were to assess the overall ...[more]
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