Transcription profiling of tumors from the melanoblastoma bearing Libechov Minipig (MeLiM) model at 8 to 91 days after birth

ABSTRACT: Spontaneous regression is a well defined phenomenon commonly observed in human melanoma in its partial histopathological form but sporadically in its complete expression. Molecular mechanisms which might be involved in spontaneous regression are poorly understood so far. The Melanoblastoma bearing Libechov Minipig (MeLiM) model exhibits cutaneous melanomas which appear in utero or shortly after birth. These lesions are clinically and histologically highly comparable to their human counterparts. Nevertheless, in swine most of the highly invasive melanomas undergo complete spontaneous regression. Induction of regression is expressed by clinical features including changes in color, drying aspect and decrease in size; histologically we observed infiltration of histiocyte-like cells, fibrosis a

ORGANISM(S): Sus scrofa

SUBMITTER: Sylvain Baulande 

PROVIDER: E-MEXP-1152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress