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Transcription profiling of mouse SAP102 and PSD-95 knockouts compared to their wild-type littermates

ABSTRACT: Effect of ablation of SAP102 or PSD-95 genes in mice compared to wild-types littermates

ORGANISM(S): Mus musculus

SUBMITTER: Luis Valor

PROVIDER: E-MEXP-1159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clustered gene expression changes flank targeted gene loci in knockout mice.

Valor Luis M LM Grant Seth G N SG

PloS one 20071212 12

<h4>Background</h4>Gene expression profiling using microarrays is a powerful technology widely used to study regulatory networks. Profiling of mRNA levels in mutant organisms has the potential to identify genes regulated by the mutated protein.<h4>Methodology/principle findings</h4>Using tissues from multiple lines of knockout mice we have examined genome-wide changes in gene expression. We report that a significant proportion of changed genes were found near the targeted gene.<h4>Conclusions/si ...[more]

PMID: 18074027

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