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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human HeLa cells follwing siRNA mediated knock down of the arginine methyltransferases CARM1 and/or PRMT1

ABSTRACT: siRNA mediated knockdown of the arginine methyltransferases CARM1 and/or PRMT1 in HeLa cells

INSTRUMENT(S): ScanArray Express HT [PerkinElmer]

ORGANISM(S): Homo sapiens

SUBMITTER: Uta-Maria Bauer

PROVIDER: E-MEXP-1173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation.

Kleinschmidt Markus A MA Streubel Gundula G Samans Birgit B Krause Michael M Bauer Uta-Maria UM

Nucleic acids research 20080415 10

Protein arginine methyltransferases (PRMT) have been implicated in the regulation of transcription. They are recruited to promoters via interaction with transcription factors and exert their coactivator function by methylating arginine residues in histones and other chromatin proteins. Here, we employ an unbiased approach to identify novel target genes, which are under the control of two members of the enzyme family, PRMT1 and CARM1/PRMT4 (coactivator associated arginine methyltransferase 1). By ...[more]

PMID: 18413343

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