Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human colorectal cancer epithelial (HCT116) p53 null cells treated with SN38 for 6, 12 and 24h

ABSTRACT: HCT116 p53 null cells were treated with 5nM SN38 (active metabolite of CPT-11) for 6, 12 and 24h. Following this RNA was harvested for transcriptional profiling.

INSTRUMENT(S): GeneChip Scanner 3000 [Affymetrix]

ORGANISM(S): Homo sapiens

SUBMITTER: wendy allen 

PROVIDER: E-MEXP-1194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.

Allen Wendy L WL   Turkington Richard C RC   Stevenson Leanne L   Carson Gail G   Coyle Vicky M VM   Hector Suzanne S   Dunne Philip P   Van Schaeybroeck Sandra S   Longley Daniel B DB   Johnston Patrick G PG  

Molecular cancer therapeutics 20120604 8

The topoisomerase I inhibitor irinotecan is used to treat advanced colorectal cancer and has been shown to have p53-independent anticancer activity. The aim of this study was to identify the p53-independent signaling mechanisms activated by irinotecan. Transcriptional profiling of isogenic HCT116 p53 wild-type and p53 null cells was carried out following treatment with the active metabolite of irinotecan, SN38. Unsupervised analysis methods showed that p53 status had a highly significant impact  ...[more]

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