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Transcription profiling of rat to investigate effects of hyperglycaemi and genetic background on gene expression

ABSTRACT: Effects of hyperglycaemia and genetic background differences on renal gene expression

ORGANISM(S): Rattus norvegicus

SUBMITTER: Dominique Gauguier 

PROVIDER: E-MEXP-1195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.

Wilder Steven P SP   Kaisaki Pamela J PJ   Argoud Karène K   Salhan Anita A   Ragoussis Jiannis J   Bihoreau Marie-Thérèse MT   Gauguier Dominique D  

BMC genomics 20090205

<h4>Background</h4>Microarray technologies are widely used to quantify the abundance of transcripts corresponding to thousands of genes. To maximise the robustness of transcriptome results, we have tested the performance and reproducibility of rat and mouse gene expression data obtained with Affymetrix, Illumina and Operon platforms.<h4>Results</h4>We present a thorough analysis of the degree of reproducibility provided by analysing the transcriptomic profile of the same animals of several exper  ...[more]

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