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Transcription profiling of leukemic cells of monozygotic twins

ABSTRACT: We established gene expression profiles of diagnostic bone marrow samples of monozygotic twins with acute lymphoblastic leukemia. We established technical duplicates for each twin.

ORGANISM(S): Homo sapiens

SUBMITTER: Beat Schafer

PROVIDER: E-MEXP-122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Prenatal origin of separate evolution of leukemia in identical twins.

Teuffel O O Betts D R DR Dettling M M Schaub R R Schäfer B W BW Niggli F K FK

Leukemia 20041001 10

Several studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia (ALL) frequently arises before birth. A prenatal origin of childhood leukemia was further supported by the detection of clonotypic immunoglobulin gene rearrangements on neonatal blood spots of children with various other subtypes of ALL. However, no comprehensive study is available linking ...[more]

PMID: 15356660

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