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Transcription profiling by array of pancreatic cells from C57BL/6 mice following dibenzazepine treatment

ABSTRACT: DBZ (dibenzazepine) treatment in C57BL/6 mice, pancreatic gene expression

ORGANISM(S): Mus musculus

SUBMITTER: Jens Siveke

PROVIDER: E-MEXP-1276 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Notch signaling is required for exocrine regeneration after acute pancreatitis.

Siveke Jens T JT Lubeseder-Martellato Clara C Lee Marcel M Mazur Pawel K PK Nakhai Hassan H Radtke Freddy F Schmid Roland M RM

Gastroenterology 20071104 2

<h4>Background & aims</h4>The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling in cerulein-induced pancreatitis in mice.<h4>Methods</h4>Acute pancreatitis was induced by cerulein treatment in mice treated with the gamma-secretase inhibitor dibenzazepin ...[more]

PMID: 18242220

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