Transcription profiling of human VHL treated A498 renal cancer cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Edward Oakeley
PROVIDER: E-MEXP-13 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
Staller Peter P Sulitkova Jitka J Lisztwan Joanna J Moch Holger H Oakeley Edward J EJ Krek Wilhelm W
Nature 20030901 6955
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metastasize to organs that are an abundant source of the CXCR4-specific ligand stromal cell-derived factor-1alpha (ref. 1). It is still uncertain how an evolving tumour cell is reprogrammed to express CXCR4, thus implementing the tendency to metastasize to ...[more]
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